Category: Seminars and Conferences
State: Current
June 30th, 10.00 am

From cells to circuits, finding latent signals of neural degeneration

Conference room “Luigi Ciminiera” (5. floor) of the Department of Control and Computer Engineering

Seminar From cells to circuits, finding latent signals of neural degeneration, held by Dr. Genevieve Stein-O'Brien

When: Monday June 30th, 10.00 am
Where: Conference room “Luigi Ciminiera” (5. floor) of the Department of Control and Computer Engineering
Speaker: Genevieve Stein-O'Brien, Johns Hopkins University (USA)

Abstract: Neurodegenerative diseases show complex, heterogeneous pathologies with eight shared hallmarks, including protein aggregation, synaptic dysfunction, altered proteostasis, and neuroinflammation, leading to neuronal death. Dr. Stein-O'Brien will discuss available data types and opportunities for multimodal integration. Drawing on her expertise in latent space techniques, she will highlight successes with matrix decomposition, transfer learning, and ongoing work using transformers.

Bio: Dr. Stein-O'Brien is a Bloomberg Assistant Professor at Johns Hopkins in Neurology, Neuroscience, Genomic Medicine, and Oncology, with ties to Kavli, Convergence, and IDIES. She co-founded and is Assistant Director of the Single-cell Training and Analysis Center. A leader in computational biology, she advances transfer learning, matrix factorization, and spatial multi-omics for dynamic cellular systems.

Contacts:
- Lorenzo Martini: lorenzo.martini@polito.it