From cells to circuits, finding latent signals of neural degeneration
Seminario From cells to circuits, finding latent signals of neural degeneration, tenuto dalla dott.ssa Genevieve Stein-O'Brien
Quando: Lunedì 30 giugno, ore 10.00
Dove: Sala Ciminiera (5° piano) del Dipartimento di Automatica e Informatica
Relatore: Genevieve Stein-O'Brien, Johns Hopkins University (USA)
Abstract: Neurodegenerative diseases show complex, heterogeneous pathologies with eight shared hallmarks, including protein aggregation, synaptic dysfunction, altered proteostasis, and neuroinflammation, leading to neuronal death. Dr. Stein-O'Brien will discuss available data types and opportunities for multimodal integration. Drawing on her expertise in latent space techniques, she will highlight successes with matrix decomposition, transfer learning, and ongoing work using transformers.
Bio: Dr. Stein-O'Brien is a Bloomberg Assistant Professor at Johns Hopkins in Neurology, Neuroscience, Genomic Medicine, and Oncology, with ties to Kavli, Convergence, and IDIES. She co-founded and is Assistant Director of the Single-cell Training and Analysis Center. A leader in computational biology, she advances transfer learning, matrix factorization, and spatial multi-omics for dynamic cellular systems.
Per ulteriori informazioni contattare:
- Lorenzo Martini: lorenzo.martini@polito.it
(1 MB)